General Information

  • ID:  hor005197
  • Uniprot ID:  P30802
  • Protein name:  Galanin
  • Gene name:  GAL
  • Organism:  Gallus gallus (Chicken)
  • Family:  Galanin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GWTLNSAGYLLGPHAVDNHRSFNDKHGFT
  • Length:  29(1-29)
  • Propeptide:  GWTLNSAGYLLGPHAVDNHRSFNDKHGFT
  • Signal peptide:  NA
  • Modification:  T29 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  The GAL is the main peptide in chick embryo sympathetic respiratory system.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  GALR1
  • Target Unid:  B2ZE94
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P30802-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P30802-F1.pdbhor005197_AF2.pdbhor005197_ESM.pdb

Physical Information

Mass: 371211 Formula: C144H207N43O42
Absent amino acids: CEIMQ Common amino acids: G
pI: 7.8 Basic residues: 5
Polar residues: 12 Hydrophobic residues: 9
Hydrophobicity: -65.86 Boman Index: -4942
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 57.24
Instability Index: 895.52 Extinction Coefficient cystines: 6990
Absorbance 280nm: 249.64

Literature

  • PubMed ID:  1715289
  • Title:  Chemical detection of natural peptides by specific structures. Isolation of chicken galanin by monitoring for its N-terminal dipeptide, and determination of the amino acid sequence.
  • PubMed ID:  16633821
  • Title:   Early development of chick embryo respiratory nervous system: an immuno